9 Health Benefits of Lion’s Mane Mushroom (Plus Side Effects) (2024)

Lion’s mane mushrooms are large, white, shaggy mushrooms that resemble a lion’s mane as they grow. They contain bioactive substances that have many beneficial effects on the body, especially the brain, heart, and gut.

Lion’s mane mushrooms, also known as Hericium erinaceus, hou tou gu or yamabush*take, have both culinary and medicinal uses in Asian countries like China, India, Japan, and Korea (1).

Here are nine health benefits of lion’s mane mushrooms and their extracts, along with dosages, preparation, and side effects.

1. Could protect against dementia

The brain’s ability to grow and form new connections typically declines with age, which may explain why mental functioning worsens in many older adults (2).

Studies have found that lion’s mane mushrooms contain two special compounds that can stimulate the growth of brain cells: hericenones and erinacines (3).

Additionally, animal studies have found that lion’s mane may help protect against Alzheimer’s disease, a degenerative brain disease that causes progressive memory loss.

In fact, lion’s mane mushroom and its extracts have been shown to reduce symptoms of memory loss in mice, as well as prevent neuronal damage caused by amyloid-beta plaques, which accumulate in the brain during Alzheimer’s disease (4, 5, 6).

A 2020 study of people with mild Alzheimer’s disease found that supplementation with 1 gram of lion’s mane mushroom daily for 49 weeks significantly improved cognitive test scores compared with a placebo (7).

The ability of lion’s mane mushroom to promote nerve growth and protect the brain from Alzheimer’s-related damage may explain some of its beneficial effects on brain health.

However, it’s important to note that most of the research has been conducted on animals or in test tubes. Therefore, more human studies are needed.


Lion’s mane mushrooms contain compounds that stimulate brain cell growth and protect them from damage caused by Alzheimer’s disease. However, more research involving humans is needed.

2. Helps relieve mild symptoms of depression and anxiety

Up to one-third of people living in developed countries experience symptoms of anxiety and depression (8, 9).

While there are many causes of anxiety and depression, chronic inflammation could be a major contributing factor.

Animal research has found that lion’s mane mushroom extract has anti-inflammatory effects that can reduce symptoms of anxiety and depression in mice (10).

Other animal studies have found that lion’s mane extract can also help regenerate brain cells and improve the functioning of the hippocampus, a region of the brain that processes memories and emotional responses (11, 12).

Researchers believe that improved hippocampus functioning may explain the reductions in anxious and depressive behaviors in mice receiving these extracts.

While these animal studies are promising, there is very little research involving humans.

One small 2010 study of menopausal women found that eating cookies containing lion’s mane mushrooms daily for 1 month helped reduce self-reported feelings of irritation and anxiety (13, 14).


Studies suggest that lion’s mane mushrooms may help relieve mild symptoms of anxiety and depression, but more research involving humans is needed to better understand the correlation.

3. May speed recovery from nervous system injuries

The nervous system consists of the brain, spinal cord, and other nerves that travel throughout the body. These components work together to send and transmit signals that control almost every bodily function.

Brain or spinal cord injuries can cause various adverse medical outcomes. They often cause paralysis or loss of mental functions and can take a long time to heal.

However, research has found that lion’s mane mushroom extract may help speed recovery from these types of injuries by stimulating the growth and repair of nerve cells (15, 16). It may also help reduce the severity of brain damage after a stroke.

However, no studies have been conducted involving humans to determine if lion’s mane would have the same therapeutic effect on nervous system injuries as animal research has suggested.


Rat studies have found that lion’s mane extract can speed up recovery from nervous system injuries, but research involving humans is lacking.

4. Protects against ulcers in the digestive tract

Ulcers can form anywhere along the digestive tract, including the stomach, small intestine, and large intestine.

Two major factors typically cause stomach ulcers: overgrowth of the bacteria H. pylori and damage to the mucous layer of the stomach that’s often due to long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) (17).

Lion’s mane extract may protect against the development of stomach ulcers by inhibiting the growth of H. pylori and protecting the stomach lining from damage (18).

Several older studies have found that lion’s mane extract can prevent the growth of H. pylori in a test tube, but no studies have tested whether the extract has the same effects inside the stomach (19, 20).

Another 2013 animal study found that lion’s mane extract was more effective at preventing alcohol-induced stomach ulcers than traditional acid-lowering drugs — and without any negative side effects (21).

Lion’s mane extract can also reduce inflammation and prevent tissue damage in other intestinal areas. In fact, they may help treat inflammatory bowel diseases like ulcerative colitis and Crohn’s disease (22, 23, 24).

A 2016 study of people with ulcerative colitis found that taking a mushroom supplement containing 14% lion’s mane extract significantly reduced symptoms and improved quality of life after 3 weeks (25).

However, when the same study was repeated in patients with Crohn’s disease, the benefits were roughly the same as with placebo (26).

It’s important to note that the herbal supplement used in these studies included several types of mushrooms, so it’s difficult to conclude about the effects of lion’s mane specifically.

Overall, research suggests that lion’s mane extract may help inhibit the development of ulcers, but more research involving humans is needed.


Lion’s mane extract has been shown to protect against stomach and intestinal ulcers in rodents, but research involving humans has been conflicting.

5. Reduces risk of heart disease

Major risk factors for heart disease include the following:

  • obesity
  • high triglycerides
  • large amounts of oxidized cholesterol
  • an increased tendency to get blood clots

Research shows that lion’s mane extract can influence some of these factors and reduce the risk of heart disease.

Studies of rats and mice have found that lion’s mane mushroom extract improves fat metabolism and lowers triglyceride levels (27).

One 2010 study of rats fed a high fat diet and given daily doses of lion’s mane extract showed 27% lower triglyceride levels and 42% less weight gain after 28 days (28).

Since obesity and high triglycerides are both considered risk factors for heart disease, this is one way that lion’s mane mushrooms contribute to heart health.

Test-tube studies have also found that lion’s mane extract can help prevent the oxidation of cholesterol in the bloodstream (29).

Oxidized cholesterol molecules tend to attach to artery walls, causing them to harden and increase the risk of heart attack and stroke. Reducing oxidation is beneficial for heart health.

What’s more, lion’s mane mushrooms contain a compound called hericenone B, which can decrease the rate of blood clotting and lower the risk of heart attack or stroke (30).

Lion’s mane mushrooms appear to benefit the heart and blood vessels in multiple ways, but studies involving humans are needed to support this.


Animal and test-tube studies suggest that lion’s mane extract can reduce the risk of heart disease in several ways, but human studies are needed to confirm these findings.

6. Helps manage diabetes symptoms

Diabetes is a disease that occurs when the body’s ability to manage blood sugar levels is impaired. As a result, levels are consistently elevated.

Chronically high blood sugar levels eventually cause complications like kidney disease, nerve damage in the hands and feet, and vision loss.

Lion’s mane mushroom may be beneficial for diabetes management by improving blood sugar management and reducing some of these side effects.

Several animal studies have shown that lion’s mane can cause significantly lower blood sugar levels in both normal and diabetic mice, even at daily dosages as low as 2.7 milligrams (mg) per pound (6 mg per kg) of body weight (31, 32).

One way that lion’s mane lowers blood sugars is by blocking the activity of the enzyme alpha-glucosidase, which breaks down carbs in the small intestine (33).

When this enzyme is blocked, the body is unable to digest and absorb carbs as effectively, which results in lower blood sugar levels.

In addition to lowering blood sugars, lion’s mane extract may reduce diabetic nerve pain in the hands and feet.

In mice with diabetic nerve damage, 6 weeks of daily lion’s mushroom extract significantly reduced pain, lowered blood sugar levels, and even increased antioxidant levels (34).

Lion’s mane mushroom shows potential as a therapeutic diabetes supplement, but more research is needed to determine exactly how it might be used in humans.


Lion’s mane mushroom can help lower blood sugar and reduce diabetic nerve pain in mice, but more studies are needed to determine whether it might be a good therapeutic option in humans.

»MORE:Living with diabetes? Explore our top resources.

7. May help fight cancer

Cancer occurs when your DNA becomes damaged, causing your cells to divide and replicate out of control.

Some research suggests that lion’s mane mushroom has cancer-fighting abilities thanks to several of its unique compounds (35, 36).

In fact, when lion’s mane extract is mixed with human cancer cells in a test tube, they cause the cancer cells to die faster. This has been demonstrated with several types of cancer cells, including liver, colon, stomach, and blood cancer cells (37, 38, 39, 40). However, at least one older study has failed to replicate these results (41).

In addition to killing cancer cells, lion’s mane extract has also been shown to slow the spread of cancer.

One 2013 study of mice with colon cancer found that taking lion’s mane extract reduced the spread of cancer to the lungs by 69% (42).

Another 2014 study found that lion’s mane extract was more effective than traditional cancer medications at slowing tumor growth in mice, in addition to having fewer side effects (43).

However, the anticancer effects of lion’s mane mushroom have never been tested in humans, so more research is needed.


Animal and test-tube studies show that lion’s mane extract can kill cancer cells and slow the spread of tumors, but studies involving humans are still needed.

8. Reduces inflammation and oxidative stress

Chronic inflammation and oxidative stress are believed to be the root causes of many modern illnesses, including heart disease, cancer, and autoimmune disorders (47).

Research shows that lion’s mane mushrooms contain powerful anti-inflammatory and antioxidant compounds that may help reduce the impact of these illnesses (48).

In fact, a 2012 study examining the antioxidant abilities of 14 different mushroom species found that lion’s mane had the fourth highest antioxidant activity and recommended it be considered a good dietary source of antioxidants (49).

Several animal studies have found that lion’s mane extract reduced markers of inflammation and oxidative stress in rodents and may be especially useful in managing inflammatory bowel disease, liver damage, and stroke (22, 50, 51).

Lion’s mane mushrooms may also help reduce some of the health risks associated with obesity, as they have been shown to decrease the amount of inflammation fat tissue releases (52).

More studies are needed to determine the potential health benefits in humans, but the results from lab and animal studies are promising.


Lion’s mane mushroom contains powerful antioxidant and anti-inflammatory compounds that may help reduce the impact of chronic illness.

9. Boosts the immune system

A strong immune system protects the body from bacteria, viruses, and other disease-causing pathogens.

On the other hand, a weak immune system puts the body at a higher risk of developing infectious diseases.

Animal research shows that lion’s mane mushroom can boost immunity by increasing the activity of the intestinal immune system, which protects the body from pathogens that enter the gut through the mouth or nose (53).

These effects may partly be due to beneficial changes in gut bacteria that stimulate the immune system (54).

A 2012 study even found that supplementing with lion’s mane extract daily nearly quadrupled the lifespan of mice injected with a lethal dose of salmonella bacteria (55).

The immune-boosting effects of lion’s mane mushrooms are very promising, but this area of research is still developing.


Lion’s mane mushrooms have been shown to have immune-boosting effects in rodents, but much more research is needed.

There’s no standard dosage for lion’s mane mushrooms. The safest, most beneficial amount depends on factors like your age and overall health. You may want to talk with a doctor about the right dosage for you.

For improving cognition, some researchers recommend 3 to 5 grams per day. (56)

In a 2020 study, people ages 50 and older with mild Alzheimer’s disease symptoms showed significantly improved cognitive function after taking three 350-mg lion’s mane capsules daily for 49 weeks. (7)

Taking three 400-mg capsules daily for 8 weeks helped relieve depression, anxiety, and sleep disorders for 77 people who were overweight or had obesity, according to a 2019 study. (57)


The most effective dosage of lion’s mane mushrooms depends on factors like your age and overall health.

Lion’s mane mushrooms can be enjoyed raw, cooked, dried, or steeped as tea.

Many people describe their flavor as “seafood-like,” often comparing it to crab or lobster (58).

The mushrooms can be cooked and served in dishes like risotto, pasta, or soup.

Lion’s mane mushroom powder can be mixed into hot water, tea, coffee, a smoothie, or other beverages. It can also be added to soup, stew, or gravy.


Lion’s mane mushrooms can be eaten raw, cooked, or dried.

Fresh lion’s mane mushrooms have the greatest health benefits, according to some researchers. However, the cultivation methods may affect the mushrooms’ medicinal properties. (59)

Lion’s mane mushrooms are available over the counter in some of the following forms:

  • tablets
  • capsules
  • powder
  • tinctures

However, researchers advise that there are currently no guidelines to ensure these products are safe and effective.


Although fresh lion’s mane mushrooms may provide the most health benefits, they can also be taken as a supplement in forms like tablets or capsules.

Safety and side effects

No studies involving humans have examined the side effects of lion’s mane mushroom or its extract, but they appear to be very safe.

No adverse effects have been seen in rats, even at doses as high as 2.3 grams per pound (5 grams per kg) of body weight per day for 1 month or lower dosages for 3 months (60, 61, 62).

However, anyone who is allergic or sensitive to mushrooms should avoid lion’s mane since it’s a mushroom species.

There have been documented cases of people experiencing difficulty breathing or skin rashes after exposure to lion’s mane mushrooms, likely related to allergies (63, 64).


Animal studies suggest that lion’s mane mushroom and its extracts are very safe, even at high doses. However, allergic reactions in humans have been reported, so anyone with a known mushroom allergy should avoid it.

Are lion’s mane mushrooms good for you?

Yes, they can be. Lion’s mane appears to be safe to use, as long as you speak with a doctor before you start using it and follow the instructions carefully.

What are the benefits of taking lion’s mane?

As discussed in detail above, the benefits of taking lion’s mane may include:

  • potential improvement of mild cognitive impairment
  • support for depression and anxiety symptoms
  • speed recovery from nerve injuries
  • protection against stomach ulcers
  • improved heart health
  • management of diabetes symptoms
  • cancer prevention
  • lower inflammation markers
  • improved immune function

Most studies on the benefits of lion’s mane have been on animals. More research in humans is needed to validate some of these findings.

What does lion’s mane do for the brain?

Lion’s mane contains substances that may contribute to nerve growth. Some studies have suggested that taking lion’s mane may boost thinking and memory processes. It may also help protect against Alzheimer’s and other types of dementia. However, more research is needed.

What are the negative effects of lion’s mane?

Lion’s mane mushrooms are considered safe in general, unless you’re allergic to mushrooms. No significant side effects have been reported in research, but if you experience any adverse symptoms after consuming lion’s mane, seek prompt medical attention.

Is lion’s mane good for ADHD?

Some people use lion’s mane for ADHD because of its potential to protect and enhance brain function. However, there is no scientific evidence to support this use.

Is lion’s mane illicit?

Lion’s mane is legal to buy and use in the United States. However, due to its rarity, it is a protected species in some countries and U.S. states, making foraging illegal. Check with your local regulations if you plan to forage for lion’s mane and always ensure you obtain lion’s mane from a reputable and sustainable source (65).

The bottom line

Lion’s mane mushroom and its extract may have various health benefits.

Animal studies have suggested that lion’s mane may protect against dementia, reduce mild symptoms of anxiety and depression, and help repair nerve damage.

It’s also been shown to have anti-inflammatory, antioxidant, and immune-boosting abilities and to lower the risk of heart disease, cancer, ulcers, and diabetes in animals.

While the current research is promising, more studies involving humans are needed to develop practical health applications for lion’s mane mushrooms.

9 Health Benefits of Lion’s Mane Mushroom (Plus Side Effects) (2024)


Are there any negative effects of Lion's Mane? ›

“Lion's mane is generally well tolerated, but the most common side effects include gastrointestinal discomfort, nausea and a skin rash,” says Dr. Watson. If you experience side effects, discontinue lion's mane consumption until you've spoken with a health care provider.

Who cannot take lion's mane? ›

Who Should Not Take Lion's Mane? Although Lion's Mane is generally safe, it may not be the best choice for everyone - if you have a blood clotting disorder, you're allergic to mushrooms or you're pregnant, you should proceed with caution.

What happens if you take lion's mane every day? ›

There's not much research on whether it's safe to eat or take supplements of lion's mane for a prolonged period or about their side effects. Possible allergic reactions to lion's mane mushrooms have been reported. In one case, a man developed breathing problems.

Is lions mane mushroom safe for kidneys? ›

Various types of mushrooms, such as Reishi, Cordyceps, and Lion's Mane, possess properties beneficial to kidneys, such as supporting the immune system, potentially reducing inflammation, and providing essential nutrients.

Can too much Lion's Mane make you sick? ›

“In general, culinary amounts of fresh lion's mane carries few risks,” Surampudi said but added that some people may experience nausea, abdominal discomfort, and skin rashes after consuming these mushrooms. Lion's mane supplements are also available.

What happens if you stop taking lion mane? ›

So, if you're worried about lion's mane mushrooms addiction, you can keep taking these mushrooms without any fear. Even if you're taking high doses of lion's mane, you won't experience any side effects or withdrawal symptoms once you stop taking it, although you'll also stop reaping its benefits.

Can Lion's Mane damage liver? ›

Recently, lion's mane has been purported to improve cognition and relieve anxiety and depression. Lion's mane is generally recognized as safe and has not been linked to serum enzyme elevations during therapy nor to episodes of clinically apparent liver injury.

Does lion's mane raise blood pressure? ›

Those studies showed that lion's mane can help regulate blood sugar and reduce high blood pressure, as well as other mental and brain health applications including treating depression and improving recovery after a traumatic brain injury, according to an article in Popular Science.

Is Lion's Mane FDA approved? ›


The FDA verified through post-marketing surveillance that the abovementioned food supplements are not registered and the Certificate of Product Registration (CPR) have not yet been issued.

Should you take Lion's Mane at night or morning? ›

Lion's mane mushroom brain benefits

This is why thebest time to take lion's mane mushroom is traditionally considered to be in the morning to early afternoon - to give the mushrooms a chance to work with brain function throughout the day, while you are awake.

Does Lion's Mane help with weight loss? ›

Lion's Mane mushrooms are a type of functional mushroom with health benefits that may also help you lose weight. These beneficial mushrooms are the non-psychedelic kind that may play a role in fat metabolism and support healthy body triglyceride levels (a type of fat).

How quickly does lion's mane work? ›

Depending on your biochemistry, you may feel energizing or anxiolytic effects of lion's mane after just a couple of days. Many users report decreased anxiety and increased mental clarity after 2-5 days of use. Depending, of course, on the dosage.

What is the best form of lion's mane? ›

The Top Lion's Mane Supplements in 2024
  • Best Lion's Main Mushroom Supplement: Nootrum Mushrooms.
  • Four Sigmatic Focus.
  • Nootropics Depot Lions Mane Mushroom Capsules.
  • Mushroom Wisdom Super Lion's Mane.
  • XPRS Nutra Separated Size 0 Capsules (1000 Count) with Lion's Mane Powder.
  • Lion's Mane Mushroom Meadowsweet Tea.
Feb 7, 2024

Is Lion's Mane good for liver? ›

Other areas that lion's mane has shown promise for its antioxidant (and thus possible inflammatory) benefits include positive results for inflammatory bowel disease and liver damage.

How long does lion's mane stay in your system? ›

Generally, Lion's Mane can stay in your system for up to 24 hours. However, it is important to note that this is an average and that the time can vary depending on the individual.

Is Lions Mane like Adderall? ›

Infact, according to The Guardian, lion's mane mushroom has been proved to be a great ingredient for improving cognitive performance among older adults. One of the major factors in using lion's mane mushroom compared to adderall is due to its nature of being easily abused.

Can Lion's Mane mess with hormones? ›

Hormonal Influence

Current evidence suggests that Lion's Mane may have an impact on hormonal levels, particularly in the modulation of cortisol and testosterone. While cortisol is associated with stress, testosterone is a key hormone influencing libido and mood in men.

Can lion's mane cause anxiety? ›

No, it is not common for Lion's Mane to cause anxiety. Most people tolerate Lion's Mane well and experience its potential cognitive and health benefits without adverse effects.

Is lion mane addictive? ›

Now, you might experience less brain fog, and mild improvement in symptoms relating to anxiety or depression but lion's mane will not get you high. Lion's mane is not a form of stimulation, they are not addictive, not a psychedelic or a sedative!

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